Open interactive map →Cheap flights from Santiago to Santa Cruz
Planning a trip from Santiago to Santa Cruz? Current fares start at €140 - a solid entry point for a flight to Bolivia. Several airlines compete on this route, which helps keep fares relatively stable. The cheapest fare is non-stop, so no connection time to factor into your schedule. Use the price calendar to identify your cheapest month, then click through to compare live seat availability.
For the best prices on this route, aim to book at least 3-4 weeks in advance. Tuesday and Wednesday departures from Santiago tend to be cheaper than Friday or Sunday flights. If €140 is above your budget, try adjusting to a shoulder-season month using the calendar above - fares can drop significantly outside peak periods.
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Cheapest month to fly
- October 2026€140DirectCheapest
Based on tracked fares, October is the cheapest month to fly this route at around €140.
Prices last updated: September 2026
Alternative routes
Other ways to reach Santa Cruz
Frequently asked questions
How much does a flight from Santiago to Santa Cruz cost?
The cheapest fare currently available from Santiago to Santa Cruz is €140. Prices on this route vary by season, day of week, and how far in advance you book. The month-by-month price calendar on this page shows exactly when fares are highest and lowest, so you can pick the most cost-effective window before searching for specific dates. Fares are refreshed regularly as our flight partners publish new availability.
Are there direct flights from Santiago to Santa Cruz?
Yes - non-stop flights are currently available from Santiago to Santa Cruz. The cheapest direct fare starts at €140, making it a convenient option if you want to avoid layover time. Direct flights are generally quicker and less stressful, especially for shorter trips to Bolivia. Click through to the booking site to check live availability and schedules for your dates.
When is the cheapest time to fly from Santiago to Santa Cruz?
Prices on this route typically dip during shoulder-season months, away from school holidays and public holiday windows. Mid-week departures - particularly Tuesday to Thursday - tend to be cheaper than flights on Fridays and Sundays from Santiago. The month-by-month price calendar above is the fastest way to identify the cheapest window - look for the months with the lowest fares before committing to travel dates. Booking 3-6 weeks in advance generally offers the best balance of price and seat availability on this route.