Cheap flights from Rome to South America

Rome (FCO) serves 24 destinations in South America. Recent fares have started from €368 to Sao Paulo. Open the interactive map to see all South American routes plotted visually, or browse the price table below.

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About this region

Best for: culturewildlifeadventurefood
Typical trip: 14-21 days
Typical value months(EU departures): AprilMaySeptember

Trip lengths and value months reflect typical patterns for EU-origin departures - individual routes vary.

Popular destinations in South America from Rome

The most popular destinations in South America from Rome include Sao Paulo, La Paz, Belo Horizonte, Rio de Janeiro and Santiago. Prices vary by season, airline, and how far in advance you book. The table below lists all available routes sorted by current fare.

Cheapest destinations in South America from Rome

Fly from Rome to a specific country in South America

Flights to South America from nearby airports

Milan to South America

Other regions from Rome

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Frequently asked questions

How many destinations in South America can I fly to from Rome?

SkyHopp currently tracks 24 destinations in South America from Rome (FCO). Prices are refreshed regularly as our flight partners publish new fares. The full list is in the price table above, sorted by cheapest current fare.

What is the cheapest flight from Rome to South America?

Recent fares from Rome to South America have started from €368 to Sao Paulo. Prices change frequently — check the table above for the latest available fares. Booking 4-8 weeks in advance and travelling mid-week typically unlocks the lowest prices on long-haul routes.

Which cities in South America are cheapest to fly to from Rome?

The price table above shows all destinations sorted cheapest first. Prices shift daily, but the top destinations by fare from Rome have recently included Sao Paulo. Clicking through to a destination page shows a 12-month price calendar so you can identify the cheapest month to fly.

When is the best time to fly from Rome to South America?

Shoulder-season months and mid-week departures typically offer the lowest fares on routes from Rome. For South America, the best value windows vary by destination — check the individual route pages for month-by-month price calendars. Booking further in advance is particularly important on long-haul routes, where last-minute fares tend to be significantly higher.