Cheap flights from Madrid to South America

Madrid (MAD) serves 34 destinations in South America. Recent fares have started from €305 to Santa Cruz. Open the interactive map to see all South American routes plotted visually, or browse the price table below.

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About this region

Best for: culturewildlifeadventurefood
Typical trip: 14-21 days
Typical value months(EU departures): AprilMaySeptember

Trip lengths and value months reflect typical patterns for EU-origin departures - individual routes vary.

Popular destinations in South America from Madrid

The most popular destinations in South America from Madrid include Santa Cruz, Sao Paulo, Caracas, Santiago and Recife. Prices vary by season, airline, and how far in advance you book. The table below lists all available routes sorted by current fare.

Cheapest destinations from Madrid

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Flights to South America from nearby airports

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Frequently asked questions

How many destinations in South America can I fly to from Madrid?

SkyHopp currently tracks 34 destinations in South America from Madrid (MAD). Prices are refreshed regularly as our flight partners publish new fares. The full list is in the price table above, sorted by cheapest current fare.

What is the cheapest flight from Madrid to South America?

Recent fares from Madrid to South America have started from €305 to Santa Cruz. Prices change frequently — check the table above for the latest available fares. Booking 4-8 weeks in advance and travelling mid-week typically unlocks the lowest prices on long-haul routes.

Which cities in South America are cheapest to fly to from Madrid?

The price table above shows all destinations sorted cheapest first. Prices shift daily, but the top destinations by fare from Madrid have recently included Santa Cruz. Clicking through to a destination page shows a 12-month price calendar so you can identify the cheapest month to fly.

When is the best time to fly from Madrid to South America?

Shoulder-season months and mid-week departures typically offer the lowest fares on routes from Madrid. For South America, the best value windows vary by destination — check the individual route pages for month-by-month price calendars. Booking further in advance is particularly important on long-haul routes, where last-minute fares tend to be significantly higher.